PM.20.043 – A wearable device for continuous cardiac monitoring.

Route: Personalised medicine: the individual at the centre

Cluster question: 095 How can we personalise health care, for example by using biomarkers?

The burden of heart failure on the Dutch population remains unacceptably high with an estimated 40.000 admissions per year, and even higher re-admission rates, with significant ( 800 M EUR/year) health care expenditure. Surveillance of heart failure patients is poor due to the limited value of conventional markers (- weight, blood pressure, and symptoms) and infrequently clinical check-up. Intensive monitoring of these patients is key to avoid congestive episodes and readmission. In this project, we will extend current state-of-the-art wearable biosensors (bioimpedance, heart rate, blood pressure, respiratory rate, activity duration ) with a wearable cardiac micro-ultrasound system for monitoring of stroke volume, and cardiac output, wall-motion, and myocardial stiffness. Our consortium (TU Delft, Erasmus MC, Medical Delta 2.0 framework, TU Eindhoven) has internationally led the miniaturization of ultrasound probes over the past 10 years, and we will extend this with in-chip digitization and integration with the biosensors. All data will be collected by a smart phone that processes that information using sophisticated and personalized modelling software directing the patient to take action; whether to contact their physician and/or adjust medication. Tasks in this large-scale project (10 PhD and postdocs, 10+ staff) will cover design and prototyping of (i) the micro-ultrasound system, (ii) supervised learning algorithms for ultrasound data processing, (iii) learning algorithms for unsupervised decision making, and (iv) clinical validation and implementation. In task (iv), we will also use current wired analogue wearable probes and biosensors to monitor a group of 100 patients in early phase of the project, and follow their condition over the remaining time of the project, providing wealth of data for tasks (ii) and (iii). The consortium will include collaboration with world-players in ultrasound manufacturing (Philips, MINDRAY/Zonare, Vermon, Oldelft), engineers, and clinicians.


digital health, heart failure., M-health, wearables

Other organisations

Consortium: TU Delft (TUD), Eindhoven University of Technology (TU/e), Erasmus Medical Center (EMC), Medical Delta 2.0 framework


Organisation Erasmus Medical Center Rotterdam (EMC)
Name Dr. H.J. (Rik) Vos