PM.20.030 – Personalized treatment in chronic inflammatory disorders: From suppression of the immune response to patient involvement and integral management of disease modifiers

Route: Personalised medicine: the individual at the centre

Cluster question: 072 How do a healthy lifestyle and wholesome habits promote good health and prevent illness?

Personalised and multidisciplinary approaches are needed to improve quality of life and reduce costs of prevalent chronic immune-mediated inflammatory disorders (IMIDs). A complex interaction between a genetically altered immune response, the gut microbiota and environmental factors underlies IMIDs, contributing to the heterogeneous clinical presentation and treatment response. Current treatment strategies focus on immunosuppression, while lifestyle-related disease modifiers are hardly addressed. Diet, physical activity, sleep, psychosocial factors and patient preferences do however clearly influence disease course, but also nutritional status, fatigue, and overall wellbeing. To investigate tailored treatment and life style advice in heterogeneous IMIDs, large patient cohorts with detailed long-term follow-up are needed. Inflammatory Bowel Diseases (IBD) is used as model for IMIDs. The multidisciplinary consortium aims to implement integrated multi-domain monitoring of IBD patients to enable personalized value-based health care. Key objectives are:
1) setting up long-term multi-domain monitoring of patients across the Netherlands
2) identifying lifestyle factors influencing disease course and patient reported outcomes
3) developing tailored web-based learnings for lifestyle changes
4) implementing personalized advice in clinical practice and increase knowledge among stakeholders
We will use established telemedicine tools for safe monitoring of disease course that will be enriched with relevant wearables and digital assessments of diet, sleep, physical activity, and psychosocial factors, collectively aiming to include 3000 patients with long-term follow-up. This will be combined with targeted intervention studies, in-depth analyses in subgroups and patient experiences. All information will be used to identify relevant disease modifiers and to develop personalised advice and tailored e-learnings, ultimately improving disease course and general wellbeing.

Keywords

holisitic approach, Immune-mediated inflammatory disorders (IMIDs), Inflammatory Bowel Disease (IBD), lifestyle, personalised care

Other organisations

Amsterdam University Medical Center (Amsterdam UMC), Crohn en Colitis Ulcerosa Vereniging Nederland, Dutch Association for Dietitians, Erasmus Medical Center (EMC), Leiden Universitair Medisch Centrum (LUMC), Somt University, TNO, Universitair Medisch Centrum Groningen (UMCG), Wageningen Universities and Research (WUR)

Submitter

Organisation Maastricht University (UM)
Name Dr. Daisy Jonkers
E-mail d.jonkers@maastrichtuniversity.nl
Website https://www.maastrichtuniversity.nl/d.jonkers