PM.20.008 – Netherlands Sudden Cardiac Arrest Network (NET-SCAN)

Route: Personalised medicine: the individual at the centre

Cluster question: 088 How can we predict, prevent, and treat cardiovascular diseases (atherosclerosis, heart failure, heart arrhythmia, and thrombosis) in individuals at an early stage?

Sudden Cardiac Arrest (SCA) causes 20% of mortality in the Netherlands and mostly occurs out-of-hospital. The NET-SCAN consortium aims to solve the problem of SCA by focusing both on prevention of SCA, and optimal treatment of SCA (resuscitation care). Accordingly, it aims to elucidate the multiple interacting inherited and acquired factors that may differ between individuals. This knowledge may serve as a basis for personalized prevention strategies, and to develop improved resuscitation strategies that take the SCA victim’s individual characteristics into account. Key strengths: nationwide consortium that includes all key SCA researchers and stakeholders in academia and patient care and uniquely large SCA cohorts in the Netherlands, along with key national and international commercial partners. Key innovations: research will not be limited to patients in cardiologist care, because 50% of SCA victims were unknown to the cardiologist when SCA occurred, and had no cardiologist files; these individuals were only in general practitioner (GP) care. NET-SCAN will be unique by making their GP files accessible for SCA research, and it will utilize state-of-the-art analysis methods including machine learning and genome-wide DNA analysis. Translational outlook: the scientific findings will be translated into clinical care, e.g., by implementing a pharmacogenetic passport that will prevent the prescription and dispensing of widely used common drugs (including drugs for noncardiac disease) that increase SCA risk in genetically vulnerable individuals. Societal outlook: citizen involvement will be targeted, because it is not only crucial to prevent SCA (e.g., by putting the citizen in control of the use of his/her personal pharmacogenetic passport), but also to treat SCA once it has occurred, because SCA mostly occurs in society (out-of-hospital). NET-SCAN will extend and improve existing systems by which citizen-rescuers are dispatched to SCA victims by creating a national network to coordinate such care.

Keywords

resuscitation, Sudden cardiac arrest

Other organisations

Amsterdam UMC, Hogeschool van Amsterdam (HvA), Hogeschool van Arnhem-Nijmegen (HAN), Maastricht University Medical Center (MUMC), Regionale Ambulance Voorziening Utrecht (RAVU), UMC Utrecht (UMCU), Universitair Medisch Centrum Groningen (UMCG), Universiteit Twente (UT), University Medical Center Nijmegen (UMCN), VU Medisch Centrum Amsterdam (VUMC)

Submitter

Organisation Amsterdam UMC, AMC
Name Dr. H.L. (Hanno) Tan
E-mail h.l.tan@amsterdamumc.nl