NNL.20.008 – Digital biomarkers in neuropsychological rehabilitation after brain injury

Route: NeuroLabNL: the ultimate living lab for brain, cognition and behavioural research

Cluster question: 095 How can we personalise health care, for example by using biomarkers?

Acquired brain injury (ABI) is a leading cause of morbidity, disability, and mortality worldwide. In the chronic phase, ABI survivors almost all experience some level of impairment or disability which drastically reduces their health-related quality of life. It is common practice to administer a neuropsychological assessment to obtain a cognitive profile to indicate what forms of treatment are recommended (i.e. a specific cognitive training in case specific cognitive impairments are found, i.e. a memory training for memory impairments). However, neuropsychological assessments are time consuming (2-3 hours in general) and evaluate a patient’s performance on a particular moment. Moreover, neuropsychological tests often have a poor ecological validity, meaning that they measure cognition at a (cognitive) function level which does hardly predict functioning in everyday life at the activity- and participation levels.
The aim of our project is to develop and investigate a line of mobile applications to monitor behavior and cognition over the course of time (i.e. several times a day during or after rehabilitation) focusing on everyday activities and participation. More specifically, short neuropsychological tests and paradigms that are suitable for smartphones will be developed and validated; tracking (smartphone) options will be used to evaluate activity and participation attainment. These so-called digital biomarkers make it possible to assess cognitive functioning, activities and participation over the course of time. Moreover, by using feedback, they contribute to insight in daily-life functioning which could help both the patient directly and the therapist in realizing an individualized treatment approach. The digital biomarkers could be used to evaluate changes over time and efficacy of rehabilitation treatment.


activities, brain injury, cognition, Neuropschological rehabilitation, participation

Other organisations

InterakatContour, Klimmendaal Revalidatiespecialisten, Orikami, Yellow Riders (Serious Games)


Organisation Radboud Universiteit; Klimmendaal Revalidatiespecialisten
Name Dr. D. (Dirk) Bertens
E-mail d.bertens@donders.ru.nl
Website https://www.ru.nl/personen/bertens-d/