MD.20.014 – Fast detection of virus

Route: Measuring and detecting: anything, anytime, anywhere

Cluster question: 104 How do we develop minimally invasive techniques and interventions for diagnosis, prognosis, and treatment?

Due to the SARS-COV-2 crisis, viral infections diagnosis is more challenging and relevant than ever. Most tests that are currently available are confirmation tests, based on genetic or protein analysis. As an example, FIND provides and overview of more than 700 COVID tests that are available world wide: https://www.finddx.org/covid-19/. However, the number of exploratory tests are extremely limited. In the FETpro-active project VIRUSCAN https://www.viruscanproject.eu/), TNO together with other well established consortium partners, developed such an instrument based on mass and stiffness of the viruses. This system is still very complex. In this project we have the ambition to go one step further. With the combination of microfluidics to prepare a viral sample and field enhanced Raman spectroscopy for accurate identification we should be able to develop a sophisticated and compact point of care instrument for exploratory analysis of unknown viral samples. The microfluidic chip with integrated meta surface to enable field enhanced Raman spectroscopy contains a deterministic lateral displacement module, which is able to purify the viral sample by removing debris of large sized cells and small sized proteins. Nano engineered meta surfaces consisting of an array of doublet of dielectric pillars will trap particles and will act a as Raman field enhancement. The viral particles trapped in the doublet can be identified both on the fingerprinting the Raman spectrum and the location. In this NWA project we will improve the microfluidic chip by integrating field enhanced Raman spectroscopy to a compact point of care instrument.
Persons involved: TU/e – Giampiro Gerini, VU -Johannes de Boer, EUR – Marion Koopmans, HPI (Germany), CEA-leti (France), (all to be confirmed)

Keywords

bio medical, cell, cheap, detection, early, fast, health, nano engineered surfaces, virus

Other organisations

CEA-leti (France), Eindhoven University of Technology (TU/e), EUR, HPI (Germany), TU, Vrije Universiteit Amsterdam (VU)

Submitter

Organisation TNO
Name Prof. dr. G. (Gianpiero) Gerini
E-mail giampiero.gerini@tno.nl
Website https://www.tno.nl/en/career/tno-as-an-employer/tno-employee-stories/giampiero-gerini-senior-scientist/