MD.20.013 – Safeguard Health by Intervention on chemical Exposure via Lifestyle Decisions
In our indoor and outdoor living and working environment we are exposed to a multitude of chemicals that are applied in all materials and consumer products that surround us through direct contact or inhalation. In addition, exposure to chemicals also takes place via our diet. Historically, human exposure assessment was done on a compound-by-compound basis, which has led to the situation that the knowledge on human exposure in relationship with the multitude of chemicals to which we are potentially exposed has become very unbalanced.
With this proposal, we aim to address the knowledge gap on human chemical exposure by developing and applying a simple, cheap, easy to use, non-invasive, personal sampling method to explore the individual’s external exposome within a variety of populations groups. We will apply this methodology to assess chemical exposure among different cohorts within the general population, by measuring chemicals that we know and select a priori, such as pesticides, plastic additives, flame retardants, etc, and chemicals that we still need to identify using advanced analytical-chemical identification methods. This wealth of external exposure information will be linked to internal exposure measures and clinical biomarkers. In addition, lifestyle, spatial, and psycho-social factors influencing the exposure will be evaluated. Using realistic chemical mixture scenarios derived from the exposure patterns observed we aim to elucidate biomarkers of toxicological effects using innovative toxicity profiling approaches. The role of specific life stages, lifestyles and professions in relation to chemical exposure will be explored in-depth, which enables us to study the relation between e.g. professional exposure to neurotoxic chemicals and the development of neurodegenerative diseases like Parkinson’s disease, or other diseases.
The unique combination of chemical exposure data, observed biological effects related to mixtures and lifestyle and occupational factors will be used to develop intervention strategies that are evidence-based and that will support the reduction of chemical exposure and improve health and quality of life.
chemical exposure, health, intervention, lifestyle, personal sampling, toxicity profiling
|Organisation||Vrije Universiteit Amsterdam (VU)|
|Name||Prof. Dr. M. (Marja) Lamoree|