HCR.20.065 – Metabolomics-based diagnostics for individualized health care and prevention
Metabolic phenotyping is an emergent concept in systems biology research utilizing analytical technologies for elucidation of complex human biochemistry. Metabolic profiles provide a readout of the interaction of the genome and the environment. Metabolic profiling of blood or urine allows to understand the different metabolic processes that contribute to health and disease of an individual. Therefore metabolic profiling allows the sensitive and specific diagnosis and prognosis of diseases, allows to develop strategies to monitor health and disease progression and allows patient stratification for individualized treatment and prevention. Metabolic profiling is an essential segment of molecular biomarker studies. Where genetic variation may predict risk of disease in early stages, metabolic profiling can assess the actual health state and the (progression) risk of future (multi)morbidity. We will develop and implement a high throughput metabolomics platform for large biobanks to facilitate the discover of metabolic prognostic profiles. We will develop and implement new technologies to realize high throughput and affordable metabolomics at the large scale, to apply this for cohort and intervention studies and to strive for making metabolic health profiles available to the broader population by just analysing a droplet of blood, and at the point of care. We will include in these profiling a measure of the exposure to environmental factors including nutrition, drugs, pollutants, etc.. The acquired metabolomics data will allow new opportunities to promote health with optimized personalized interventions, including diets and life style advise. These data will enable a new generation of clinical chemistry tests to assess more accurately someone’s health state, and to extend our healthy life span.
Persons involved: Prof.dr. Dorret Boomsma (UvA), prof. dr. Eline Slagboom (LUMC), prof.dr. Arfan Ikram (Erasmus MC, EMC), prof. Anton-Jan van Zonneveld (LUMC), prof. Roel Vermeulen (UU), prof. Rick Grobbee (UMCU)
exposome, Metabolomics, precision medicine, Prevention
Erasmus Medical Center (EMC), Leiden Universitair Medisch Centrum (LUMC), UMCU, Utrecht University (UU), UvA
|Name||Prof. dr. T. (Thomas) Hankemeier|