HCR.20.063 – MULTILIFE: A citizen-driven lifestyle medicine intervention for patients with depression and cardiometabolic comorbidity

Route: Health care research, sickness prevention and treatment

Cluster question: 072 How do a healthy lifestyle and wholesome habits promote good health and prevent illness?

The aim of MULTILIFE is to develop, and evaluate a peer-led lifestyle intervention, to target the needs of citizens with cardiometabolic comorbidity and depression (CMD). We will achieve this by first mapping the patient and care environment to identify CMD patients who can benefit the most from a peer-led lifestyle medicine intervention. Subsequently, in co-creation with CMD citizens, we will develop a peer-led lifestyle intervention by including evidence-based effective elements aimed at both improving diet, physical activity, sleep and mindful behavior. For this, we will follow an abbreviated form of participatory intervention mapping. For extended, online care, tele-monitoring and personalized feedback, a lifestyle box will be created with apps and home-monitoring equipment that will be integrated with a medical dashboard and the peer coaching program selected on the basis of the needs, personal preferences, and capabilities of CMD citizens.
To evaluate MULTILIFE, we will conduct an Optimization, Effectiveness, and Implementation Hybrid trial in which both clinical and cost effectiveness and implementation are evaluated. We will use a randomized controlled trial of intervention principles comparing MULTILIFE with usual care. This trial of intervention principles allows for ongoing quality improvement and modifications based on the core intervention principles of blended lifestyle care and lifestyle peer support. The primary outcome will be short- and long-term mental health problems assessed by both validated mental health inventories and ecological momentary assessment. Also we will evaluate the effect of the intervention on both biomedical and behavioral outcomes (e.g. cardiometabolic biomarkers, quality of life and lifestyle habits) as well as the cost-effectiveness and implementation in current healthcare. Evaluating the potential of MULTILIFE for patients with CMD is important because comorbid chronic illnesses, such as cardiovascular disease, type 2 diabetes and mental health problems are increasing and driving a significant portion of health care costs.


citizen science, e-health, integrated care, peer coaching

Other organisations

Hadoks, Ivo Institute, Leyden Academy of Vitality and Ageing, Tilburg University (TiU), TNO


Organisation LUMC
Name Prof. dr. J.C. (Jessica) Kiefte-de Jong
E-mail j.c.kiefte@lumc.nl